PROTECTED aims to develop expertise and protective capabilities against Endocrine Disruptors (EDs). EDs and their mixtures are a modern day health concern leading to failing ecological systems, poor agricultural production and health effects such as obesity, cancer and infertility. While analytical methods have advanced enormously, focus has been mainly on synthetic chemicals, overlooking emerging EDs and real-life multiple substance exposure. A new generation of creative, entrepreneurial and innovative early-stage researchers equipped with skills to assess and understand the real-life risk of complex mixtures of EDs and trained to convert resulting knowledge and ideas into accessible tools and services for the long-term control of potential ED risk is urgently needed.
The PROTECTED Innovative Training Network [ITN] proposes a holistic approach by providing 15 individual, personalised research projects with exposure to scientific, innovative and entrepreneurial training mobility across the ITN.
The intersectorial network is comprised of 12 training sites at academia, research centres, a bioassay technology SME, a QSAR technology SME, water provider, and animal feed supplier. Together they cover multiple disciplines including analytical science of food, feed, and environment, epidemiology, risk assessment, social science and toxicology.
This combined expertise enables a highly focused program for developing novel tools and concepts and training for the detection, analysis and improved risk assessment of EDs, especially mixture effects. Methodology will include emerging technologies; multiplexed analysis, mixture modelling, mechanistic and exposure studies, explants and cell or whole organism bioassays. The project will provide a unique and high level of training for a new generation of specialists with transferable skills and enhanced career perspectives. These specialists will ultimately aid the efficient development of future control strategies for improved health.
PROTECTED Co-ordinator Dr Lisa Connolly attended the 10th Biodetectors Conference held in Sorrento, Italy on April 6th and 7th, 2017 to promote the PROTECTED project. Lisa’s oral presentation covered the background, aims and objectives of PROTECTED. The meeting brought together scientists involved in the development and application of in vitro effect based bioanalysis technologies. This event was sponsored by PROTECTED consortium member BioDetection Systems.
Train new researchers
To train a new generation of young researchers with multi-disciplinary skills needed in the emerging field of EDs, their mixtures and impacts on health.
Develop analysis capabilities
To develop innovative analysis capabilities for the risk assessment and communication of the impact of EDs and their mixtures on health and environment.
To expand Analytical tools in the areas of Human Health, Environmental Health and Industrial Sustainability. And to promote these tools as part of the project.
Develop Communication strategies in the areas of Human Health, Environmental Health and Industrial Sustainability.
Risk Assessment Tools
To establish and grow new risk assessment tools in relation to the Project Areas.
To share Knowledge and skills between and partner academics, beneficiaries, partners and ESRs.
Lisa Connolly, Jodie Wilson, Moira Dean, Chris Elliott, Merete Eggesbø, Paul Fowler,Erik Ropstad, Steven Verhaegen, Karin Zimmer, Thomas Fraser, Katrine Eldegard, Isabelle Oswald, Gudrun Kausel, Gunnar Eriksen, Silvio Uhlig, Marc Muller, Marie -Louise Scippo, Bart Van der Burg, Rafael Gozalbes, Declan Billington, Marc Ruelle, Siddhartha Mandal.
The PDF can be obtained here.
The fetal ovary exhibits temporal sensitivity to a ‘real-life’ mixture of environmental chemicals. Scientific Reports; 6, 22279.
Lea, R.G., Amezaga, M.R., Loup, B., Mandon-Pépin, B., Stefansdottir, A., Filis, P., Kyle, C., Zhang, Z., Allen, C., Purdie, L., Jouneau, L., Cotinot, C., Rhind, S.M., Sinclair, K.D., Fowler, P.A. (2016).
Innovative training networks bring together universities, research centres and companies from different countries worldwide to train a new generation of researchers. The funding boosts scientific excellence and business innovation, and enhances researchers’ career prospects through developing their skills in entrepreneurship, creativity and innovation.
Joint research training, implemented by at least three partners from in and outside academia. The aim is for the researcher to experience different sectors and develop their transferable skills by working on joint research projects.
"PROTECTED aims to develop innovative analysis capabilities for the risk assessment and communication of the impact of EDs and their mixtures on health and environment."
"To expand Analytical tools in the areas of Human Health, Environmental Health and Industrial Sustainability. And to promote these tools as part of the project."
"The PROTECTED Innovative Training Network [ITN] proposes a holistic approach by providing 15 individual, personalised research projects with exposure to scientific, innovative and entrepreneurial training mobility across the ITN."
The coordinator for PROTECTion against Endocrine Disruptors;Detection, mixtures, health effects, risk assessment and communication is Dr. Lisa Connolly. Contact can be made via the links below:Institute for Global Food Security