ESR Chiara Talia attends fertility conference in Liverpool

I had the great opportunity to attend The Fertility 2018 Conference (4-6 January) which took place in Liverpool. The Joint Fertility Conference is an annual event hosted by the Association of Clinical Embryologists, British Fertility Society and the Society for Reproduction and Fertility.

The main topic of this year’s conference was “Environmental influences of reproduction” and, indeed, endocrine disruptors were mentioned in several sessions and presentations. Furthermore, Prof. Paul Fowler, my supervisor, gave a talk during the scientific update session about periconceptional health on the “Effect of prenatal exposures to environmental toxins on female reproduction”.

This was the first conference I have attended and it was indeed a good way to start the year with science!


My PhD training so far..

I started my PhD. (“Consumer Perceptions of Endocrine Disruptors in the Food Chain and the Environment”) on 5th June 2017. Having only completed a BSc. to date, I was a bit concerned that I would have the same level of research skills as my peers.

Thankfully, there is a wide range of support provided by Queen’s University Belfast to ensure all researchers brush-up on the skills they need to complete their PhD. Indeed, it is a mandatory requirement that every student completes ten “training days” (i.e. the likes of conferences, workshops or lectures) tailored to his / her individual requirements.

So far, I’ve attended the following sessions: workshops on conducting keyword searches; lectures on how to carry-out systematic reviews; and presentations delivered by current PhD. Students. By Christmas, I will have been trained in how to conduct focus groups and questionnaires (i.e. the core of my PhD.), and I will have also completed a module in Medical Statistics.

All of the above support-activities have really boosted my confidence in my ability to complete my PhD. Equipped with these newly-learned skills, I look forward to moving-on to the data-collection and analysis stages of my first study.


Presenting at FARAH Day, University of Liège

The 4th annual FARAH conferences gave me a chance to highlight the health impacts of exposure to mixtures of endocrine disrupting chemicals by studying the transactivities of the Aryl hydrocarbon Receptor (AhR) in vitro assays. That was quite a challenge for me as this is the first time I had presented at a conference with both experts and non-specialised audiences. From the conference, I learned how to talk simply and better communicate with the audiences through enthusiasm.

The Department of Fundamental and Applied Research for Animals and Health (FARAH) in the University of Liège organizes an annual scientific day called the FARAH Day. This meeting offers an opportunity for all academics, scientists, technical, administrative staff and young students to interact and exchange their research interests, and also promotes the social life within the FARAH.

Endocrine disruptors have been associated with many kinds of cancers, as well as dysfunctional reproductive systems or offspring abnormal developments. We often see the toxicity of an endocrine disruptor (e.g. dioxins) as its single effect. But humans nowadays are exposed to a ‘cocktail’ of endocrine disruptors at the same time, rather than to one compound then to the others. In this study, we found that in vitro exposure to a mixture of 29 persistent organic pollutants reduced significantly AhR activities. Particularly, the effect is profound when the mixture concentration is 75 times higher than their levels in the human blood. That can lead to an adverse effect on human health and also a possible impact on the activities of other signaling pathways, including those mediated by estrogen receptors.

Evaluation the AhR activities of individual compounds in the mixture showed that the mixture activity is much higher than the activities of each component. In other words, taking the effect of one single compound into account at once is not sufficient to study their health impact. Therefore, we need to understand the toxicity of pollutants in their natural mixture, where they act with each other to produce these cocktail effects. The study contributes to the understanding of why we should focus on the mixture effect: because of its relevance to human exposure routes and its certain effect on human health.



On 19th October I attended the first international workshop of the LIFE COMBASE Project Project (COMputational tool for the assessment and substitution of Biocidal Active substanceS of Ecotoxicological concern) where speakers representing regulatory agencies, research institutions and Universities in the area of knowledge of non-testing predictive methods where invited to participate. The LIFE-COMBASE PROJECT aims to promote the sustainable use of biocidal active substances from a life cycle perspective, which it seeks to achieve through the implementation of an online information system based on the combination of evidence-based decision support systems (EBDSS) and proven computational toxicology modelling approaches. I found the workshop to be an important training and networking opportunity, particularly as my work is focused on modelling the endocrine disruption activity using computational predictive methods.